Developing novel new therapies for retinal disease

CavtheRx is a pre-clinical stage biopharmaceutical company focused on developing innovative caveolin modulators which have been shown to regulate signal transduction pathways.  The unique mechanisms of action that provide anti-angiogenic and anti-inflammatory effects which block vascular leakage and edema suggest that caveolin modulators may have a role in addressing a wide range of chronic disease states.


Our initial development plans focus on the treatment of sight-threatening neovascular eye diseases which include neovascular age-related macular degeneration (wet AMD), the leading cause of blindness in the Western world, and diabetic retinopathy.  Despite the advances in treatment provided by anti-VEGF agents, studies have reported up to 40% of patients achieve sub-optimal BCVA results.  In vitro and in vivo models demonstrate inhibition of CNV with Cavtratin alone and a synergestic effect with anti-VEGF therapy.


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